A1 (also designated Bfl-1) is a Bcl-2 family protein that dimerizes with both Bcl-2 and Bax, and has been identified as a hematopoietic-specific, early inducible gene. Although A1 demonstrated properties similar to those of Bcl-2, its function may be more temporally regulated during myeloid differentiation and is dependent on additional growth stimuli to confer its life promoting properties. A1 is abundantly expressed in bone marrow and at low levels in other tissues. A1 expression has been correlated to stomach cancer.
Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.
Western Blot: 0.5-4ug/ml
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.