Potential anti-inflammatory agent. Selectively and irreversibly inhibits NF-kB activation by blocking TNF-a-induced phosphorylation of IkB-a without affecting constitutive IkB-a phosphorylation. Inhibits the TNF-a-induced surface expression of adhesion molecules ICAM-1, VCAM-1, and E-selectin in human endothelial cells with IC50 values of 5-10uM
DMSO or EtOH
Storage and Stability:
May be stored at 4 degrees C. For long-term storage, aliquot and store at 4 degrees C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.