Antibiotic TS155-2 is a macrocyclic lactone related to hygrolidin but produced by a different Streptomyces species. Antibiotic TS155-2 is reported to be an inhibitor of calcium entry into the cell induced by thrombin stimulation. With the exception of the original patent suggesting hypotensive, anti-platelet, anti-ischaemic and anti-inflammatory activity, no literature investigation of TS155-2 is available.
Antibiotic TS155-2 from Stretomyces sp.
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
Storage and Stability:
Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.