AGTR-2, also known as AT2, is a 7 transmembrane domain protein that belongs to the G protein-coupled receptor family 1. Both AGTR-2 and AGTR-1 bind Angiotensin II and function in the control of hemodynamics. In contrast to AGTR-1, which promotes vasoconstriction and cell proliferation, AGTR-2 inhibits growth and promotes apoptosis. In addition, Angiotensin II-induced AGTR-2 signaling induces the release of nitric oxide in the heart, kidney, and brain and participates in tissue morphogenesis and repair. Human AGTR-2 shares 92% amino acid sequence identity with mouse and rat AGTR-2.
Applications:
Suitable for use in Flow Cytometry. Other applications not tested.
Recommended Dilutions:
Flow Cytometry: 10ul labels up to 1x10e6 cells or 50ul of packed whole blood.
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C before opening. DO NOT FREEZE! Stable at 4 degrees C as an undiluted liquid. Stable for 12 months at 4 degrees C. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light.
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