A cell-permeable inhibitor of calpain 1 (Ki =120nM) and calpain 2 (Ki =230nM). Also potently inhibits cathepsin B (Ki =100nM), and cathepsin L (Ki=0.6nM). Shown to induce caspase-dependent apoptosis in human acute lymphoblastic leukemia and non-Hodgkin
Supplied as a powder.
1. ZU, D.-M., and Uckun, F. M. Clin. Cancer Res. 6, 2456-2463.
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