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Akt, Phosphorylated (Ser473) Survival Marker IHC Detection Kit, BioAssay(TM)

Cat no: A1125-20


Supplier: United States Biological
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Synthetic phosphopeptide corresponding to residues around Ser473 of mouse Akt (KLH-coupled). Detects Akt1 only when phosphorylated at serine 473. Also detects Akt2 and Akt3 only when phosphorylated at equivalent sites. Does not detect Akt phosphorylated at other sites or related kinases such as PKC and p70 S6 kinase. Akt, Phosphorylated (Ser473) Survival Marker IHC Detection Kit, BioAssay(TM) is a
Catalogue number: A1125-20
Applications: Immunohistochemistry
Size: 1Kit
References: Application References: 1. Gupta, A.K., et al., Local recurrence in head and neck cancer: relationship to radiation resistance and signal transduction. Clin. Cancer Res. 8: 885-892 (2002). Applications: IHC (paraffin). 2. Malik, S.N., et al., Immunohistochemical demonstration pf phospho-Akt in high gleason grade prostate cancer. Clin. Cancer Res. 8(4): 1168-1171 (2002). Applications: IHC (paraffin). 3. Noshita, N., et al., Akt phosphorylation and neuronal survival after traumatic brain injury in mice. Neurobiol. Dis. 9: 294-304 (2002). Applications: IHC (paraffin). 4. Roy, H.K., et al., AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis. Carcinogenesis 23: 201-205 (2002). Applications: IHC (paraffin). Background References: 1. Franke, T.F., Cell 88: 435-437 (1997). 2. Burgering, B.T., Coffer, P.J., Nature 376: 599-602 (1995). 3. Franke, T.F., et al., Cell 81: 727-736 (1995). 4. Alessi, D.R., et al., EMBO J. 15: 6541-6551 (1996). .) Cardone, M.H., et al., Science 282: 1318-1321 (1998). 6. Brunet, A., et al., Cell 96: 857-868 (1999). 7. Cantley, L.C., et al., PNAS USA 96: 4240-4245 (1999). 8. Vlahos, C., et al.,J. Biol. Chem. 269: 5241-5248 (1994) . 9. Hajduch, E., et al., FEBS Lett. 492: 199-203 (2000). 10. Cross, D.A., et al., Nature 373: 785-789 (1995). 11. Diehl, et al., Genes Dev. 12: 3499-3511 (1998). 12. Gesbert, F., et al., J. Biol. Chem. 273: 39223-39230 (2000). 13. Zhou, B.P. et al., Nat. Cell Biol. 3: 245-252 (2001). 14. Nave, B.T., et al., Biochem. J. 344: 427-431 (1999). 15. Manning, B.D., et al., Mol. Cell 4: 648-657 (2000). 16. Manning, B.D., et al., Mol. Cell 10: 151-162 (2002). 17. Inoki, K., et al., Nat. Cell Biol. 4: 648-657 (2002).

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