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Adiponectin/CTRP1-7, Antibody Sampler Set, BioAssay(TM)

Cat no: A0884-80M

Supplier: United States Biological
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Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines. One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor- a-related proteins (CTRPs) 1-7. Unlike the CTRPs, which are expressed in a wide variety of tissues, adiponectin is reported to be expressed exclusively by differentiated adipocytes. These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. Adiponectin is present in high levels in normal human plasma, but is reduced in obese subjects and often in those with increased insulin resistance and type 2 diabetes, suggesting that adiponectin may be a useful pharmacological target in various metabolic diseases. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene. Rabbit polyclonal antibodies were raised against peptide sequences corresponding to each of the target proteins. Kit Components: Adiponectin, CT (Rb x Hu): 1x25ug CTRP1, NT (Rb x Hu): 1x25ug CTRP2, NT (Rb x Hu): 1x25ug CTRP3, ID (Rb x Hu): 1x25ug CTRP4, CT (Rb x Hu): 1x25ug CTRP5, NT (Rb x Hu): 1x25ug CTRP6, CT (Rb x Hu): 1x25ug CTRP7, CT (Rb x Hu): 1x25ug Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Mouse Heart Tissue Lysate HeLa Whole Lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: A0884-80M
Reactivities: Human
Size: 1 Set
Form: Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide.
References: 1. Fantuzzi, G. et al. J. Allergy Clin. Immunol. 115, 911 (2005). 2. Tsao, T.S. et al. Euro. J. Pharmacol. 440, 213 (2002). 3. Wong, GW. et al. Proc. Natl. Acad. Sci. USA 101, 10302 (2004). 4. Lihn, AS. et al. Obes. Rev. 6, 13 (2005). 5. Shapiro, L. et al. Curr. Biol. 8, 335 (1998).

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